Pittsburgh Pirates vs San Francisco Giants Prediction, Odds, MLB Picks 8/5/2025

The Pittsburgh Pirates look to continue their dominance over the San Francisco Giants as they host the second game of their three-game series at PNC Park on Tuesday evening.

In a pitching rematch from last week's matchup that saw the Pirates secure a 2-1 victory, Logan Webb (3.31 ERA) will face off against Mike Burrows (3.88 ERA) in what could be another low-scoring affair.

The Giants enter desperate for a win to keep their Wild Card hopes alive, while Pittsburgh aims to build on their recent sweep of San Francisco in late July.

At Sporting Post, our custom prediction model blends insights from leading MLB analysts to give you a clear edge.

Instead of sorting through endless opinions, we streamline expert picks, advanced team metrics, and market trends into one place. Our AI tracks top sources and assigns a confidence score to each prediction. These are averaged into a win probability that reflects the expert consensus. It gives you a data-backed view of what the sharpest minds in MLB expect.

Pittsburgh Pirates vs. San Francisco Giants preview

The Giants arrive at PNC Park looking to settle a score after the Pirates swept them in San Francisco just last week, outscoring them 11-7 in that series.

In a rematch of last week's pitching duel, Logan Webb (3.31 ERA) squares off against Mike Burrows (3.88 ERA) after their previous matchup ended in a tight 2-1 extra-innings affair where both starters excelled.

Rafael Devers brings momentum to the Giants' lineup following his three-hit, four-RBI performance against the Mets, while Spencer Horwitz enters hot for Pittsburgh after belting two homers in Sunday's win over Colorado.

San Francisco, six games out of the final NL Wild Card spot, desperately needs to turn around their fortunes against a Pirates team that's been playing above their last-place standing when facing the Giants.

Both pitchers have been stingy, with Webb striking out 11 Pirates in their last meeting and Burrows allowing just three hits across six strong innings in the same game.

Key stats

1

The Pirates sit 12th in the National League with a .434 win percentage (49-64 record), making them significant underdogs in most matchups.

2

San Francisco holds a middle-of-the-pack 9th position in the NL with a near-.500 record (56-57), giving them a clear statistical edge over Pittsburgh.

3

The Giants have been inconsistent lately with a LWLWL recent form pattern, potentially creating betting value on game-to-game volatility.

4

Pittsburgh has shown signs of life recently (WWLLW form) despite their poor overall record, creating potential value in certain spot betting situations.

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